3. Targeted Cancer Therapy: Monoclonal Antibodies and Small-Molecule Anti-Cancer Agents


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Only available as part of a package

Outline

  • Introduction to Targeted Therapy
    •  Definitions and History
  • Monoclonal Antibodies 
    • Definition, Discovery  
    • Mechanism of Action 
    • Drug Classes 
    • Antibody-Drug Conjugates
  • Small-Molecule Agents 
    • Definition and History 
    • Tyrosine Kinase Inhibitors 
    • Other Small Molecules
  • General Approach for APs 
    • Understanding Targeted Therapies 
    • Obtaining Consent 
    • Considerations for Special Populations

After completing this educational activity, participants should be able to:

  • Describe the mechanisms of action for common targeted therapies, including monoclonal antibodies and small-molecule targeted agents
  • Describe the unique characteristics of common classes of targeted therapies
  • Develop an approach for understanding new agents in this rapidly growing field

Jennifer Jacky

MSN, ARNP, AOCNP®

Fred Hutchinson Cancer Center, University of Washington

Ms. Jacky is a is a board-certified oncology nurse practitioner specializing in thoracic and head and neck malignancies. She works as an APP lead at the Fred Hutchinson Cancer Center. Her interests include clinical trials, optimizing symptom control, and primary palliative care.

Jennifer Jacky has no relevant financial relationships to disclose.

Gabrielle Zecha

PA-C, MHA

Fred Hutchinson Cancer Center, University of Washington

Ms. Zecha is a board-certified PA who specializes in the treatment of blood disorders and is the director for the more than 200 advanced practice providers in oncology and stem cell transplant at the Fred Hutchinson Cancer Center and the University of Washington. She has spent her career in oncology in a diverse array of settings, including stem cell transplant, general oncology, and hematologic malignancies.

Gabrielle Zecha has no relevant financial relationships to disclose.

Key:

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Introduction to Targeted Therapy (6 min.)
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Introduction to Targeted Therapy - Knowledge Check
1 Question  |  Unlimited attempts  |  0/1 points to pass
1 Question  |  Unlimited attempts  |  0/1 points to pass Knowledge Check grades DO NOT COUNT towards earning your CE certificate. This is your opportunity to test your knowledge. Please note: You will be informed that you passed at the end of the Knowledge Check.
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Monoclonal Antibodies (12 min.)
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Monoclonal Antibodies - Knowledge Check
1 Question  |  Unlimited attempts  |  0/1 points to pass
1 Question  |  Unlimited attempts  |  0/1 points to pass Knowledge Check grades DO NOT COUNT towards earning your CE certificate. This is your opportunity to test your knowledge. Please note: You will be informed that you passed at the end of the Knowledge Check.
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Clinical Pearls - Understanding and Managing mAbs (6 min.)
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Clinical Pearls - Understanding and Managing mAbs - Knowledge Check
2 Questions  |  Unlimited attempts  |  0/2 points to pass
2 Questions  |  Unlimited attempts  |  0/2 points to pass Knowledge Check grades DO NOT COUNT towards earning your CE certificate. This is your opportunity to test your knowledge. Please note: You will be informed that you passed at the end of the Knowledge Check.
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Antibody–Drug Conjugates (6 min.)
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Antibody–Drug Conjugates - Knowledge Check
2 Questions  |  Unlimited attempts  |  0/2 points to pass
2 Questions  |  Unlimited attempts  |  0/2 points to pass Knowledge Check grades DO NOT COUNT towards earning your CE certificate. This is your opportunity to test your knowledge. Please note: You will be informed that you passed at the end of the Knowledge Check.
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Small-Molecule Agents (13 min.)
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Small-Molecule Agents - Knowledge Check
4 Questions  |  Unlimited attempts  |  0/4 points to pass
4 Questions  |  Unlimited attempts  |  0/4 points to pass Knowledge Check grades DO NOT COUNT towards earning your CE certificate. This is your opportunity to test your knowledge. Please note: You will be informed that you passed at the end of the Knowledge Check.
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General Approach for APs (7 min.)
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Targeted Cancer Therapy Monoclonal Antibodies and Small-Molecule Anti-Cancer Agents - Post Test
11 Questions  |  3 attempts  |  9/11 points to pass
11 Questions  |  3 attempts  |  9/11 points to pass This Post Test counts towards your CE Certificate. You must answer at least 9 of 11 questions correctly to earn credit for this module. You have 3 attempts to pass the Post Test.
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